| 2021-08-13 20:00:00August 13, 2021 |   Valencia vs Getafe | 1 - 0 | N/A |
| 2021-08-14 16:00:00August 14, 2021 |   Osasuna vs Espanyol | 0 - 0 | N/A |
| 2021-08-14 18:30:00August 14, 2021 |   Mallorca vs Real Betis | 1 - 1 | N/A |
| 2021-08-14 18:30:00August 14, 2021 |   Cadiz vs Levante | 1 - 1 | N/A |
| 2021-08-14 21:00:00August 14, 2021 |   Alaves vs Real Madrid | 1 - 4 | N/A |
| 2021-08-15 16:30:00August 15, 2021 |   Celta vs Atletico Madrid | 1 - 2 | N/A |
| 2021-08-15 19:00:00August 15, 2021 |   Barcelona vs Real Sociedad | 4 - 2 | N/A |
| 2021-08-15 21:15:00August 15, 2021 |   Sevilla vs Vallecano | 3 - 0 | N/A |
| 2021-08-16 19:00:00August 16, 2021 |   Villarreal vs Granada | 0 - 0 | N/A |
| 2021-08-16 21:00:00August 16, 2021 |   Elche vs Athletic Club | 0 - 0 | N/A |
| 2021-08-20 20:00:00August 20, 2021 | Real Betis vs Cadiz | 1 - 1 | N/A |
| 2021-08-21 16:00:00August 21, 2021 | Alaves vs Mallorca | 0 - 1 | N/A |
| 2021-08-21 18:30:00August 21, 2021 | Granada vs Valencia | 1 - 1 | N/A |
| 2021-08-21 18:30:00August 21, 2021 | Espanyol vs Villarreal | 0 - 0 | N/A |
| 2021-08-21 21:00:00August 21, 2021 | Athletic Club vs Barcelona | 1 - 1 | N/A |
| 2021-08-22 16:00:00August 22, 2021 | Real Sociedad vs Vallecano | 1 - 0 | N/A |
| 2021-08-22 18:30:00August 22, 2021 | Atletico Madrid vs Elche | 1 - 0 | N/A |
| 2021-08-22 19:00:00August 22, 2021 | Getafe vs Sevilla | 0 - 1 | N/A |
| 2021-08-22 21:00:00August 22, 2021 | Levante vs Real Madrid | 3 - 3 | N/A |
| 2021-08-23 21:00:00August 23, 2021 | Osasuna vs Celta | 0 - 0 | N/A |
| 2021-08-27 19:00:00August 27, 2021 | Mallorca vs Espanyol | 1 - 0 | N/A |
| 2021-08-27 21:15:00August 27, 2021 | Valencia vs Alaves | 3 - 0 | N/A |
| 2021-08-28 16:00:00August 28, 2021 | Celta vs Athletic Club | 0 - 1 | N/A |
| 2021-08-28 18:30:00August 28, 2021 | Elche vs Sevilla | 1 - 1 | N/A |
| 2021-08-28 21:00:00August 28, 2021 | Real Betis vs Real Madrid | 0 - 1 | N/A |
| 2021-08-29 16:00:00August 29, 2021 | Barcelona vs Getafe | 2 - 1 | N/A |
| 2021-08-29 18:30:00August 29, 2021 | Cadiz vs Osasuna | 2 - 3 | N/A |
| 2021-08-29 18:30:00August 29, 2021 | Real Sociedad vs Levante | 1 - 0 | N/A |
| 2021-08-29 18:30:00August 29, 2021 | Vallecano vs Granada | 4 - 0 | N/A |
| 2021-08-29 21:00:00August 29, 2021 | Atletico Madrid vs Villarreal | 2 - 2 | N/A |
| 2021-09-11 17:30:00September 11, 2021 | Levante vs Vallecano | 1 - 1 | N/A |
| 2021-09-11 20:00:00September 11, 2021 | Athletic Club vs Mallorca | 2 - 0 | N/A |
| 2021-09-12 13:00:00September 12, 2021 | Espanyol vs Atletico Madrid | 1 - 2 | N/A |
| 2021-09-12 15:15:00September 12, 2021 | Osasuna vs Valencia | 1 - 4 | N/A |
| 2021-09-12 17:30:00September 12, 2021 | Cadiz vs Real Sociedad | 0 - 2 | N/A |
| 2021-09-12 20:00:00September 12, 2021 | Real Madrid vs Celta | 5 - 2 | N/A |
| 2021-09-13 19:00:00September 13, 2021 | Getafe vs Elche | 0 - 1 | N/A |
| 2021-09-13 21:00:00September 13, 2021 | Granada vs Real Betis | 1 - 2 | N/A |
| 2021-09-17 20:00:00September 17, 2021 | Celta vs Cadiz | 1 - 2 | N/A |
| 2021-09-18 13:00:00September 18, 2021 | Vallecano vs Getafe | 3 - 0 | N/A |
| 2021-09-18 15:15:00September 18, 2021 | Atletico Madrid vs Athletic Club | 0 - 0 | N/A |
| 2021-09-18 17:30:00September 18, 2021 | Elche vs Levante | 1 - 1 | N/A |
| 2021-09-18 20:00:00September 18, 2021 | Alaves vs Osasuna | 0 - 2 | N/A |
| 2021-09-19 13:00:00September 19, 2021 | Mallorca vs Villarreal | 0 - 0 | N/A |
| 2021-09-19 15:15:00September 19, 2021 | Real Sociedad vs Sevilla | 0 - 0 | N/A |
| 2021-09-19 17:30:00September 19, 2021 | Real Betis vs Espanyol | 2 - 2 | N/A |
| 2021-09-19 20:00:00September 19, 2021 | Valencia vs Real Madrid | 1 - 2 | N/A |
| 2021-09-20 20:00:00September 20, 2021 | Barcelona vs Granada | 1 - 1 | N/A |
| 2021-09-21 18:30:00September 21, 2021 | Getafe vs Atletico Madrid | 1 - 2 | N/A |
| 2021-09-21 21:00:00September 21, 2021 | Athletic Club vs Vallecano | 1 - 2 | N/A |
| 2021-09-21 21:00:00September 21, 2021 | Levante vs Celta | 0 - 2 | N/A |
| 2021-09-22 18:30:00September 22, 2021 | Espanyol vs Alaves | 1 - 0 | N/A |
| 2021-09-22 18:30:00September 22, 2021 | Sevilla vs Valencia | 3 - 1 | N/A |
| 2021-09-22 21:00:00September 22, 2021 | Real Madrid vs Mallorca | 6 - 1 | N/A |
| 2021-09-22 21:00:00September 22, 2021 | Villarreal vs Elche | 4 - 1 | N/A |
| 2021-09-23 18:30:00September 23, 2021 | Granada vs Real Sociedad | 2 - 3 | N/A |
| 2021-09-23 18:30:00September 23, 2021 | Osasuna vs Real Betis | 1 - 3 | N/A |
| 2021-09-23 21:00:00September 23, 2021 | Cadiz vs Barcelona | 0 - 0 | N/A |
| 2021-09-25 13:00:00September 25, 2021 | Alaves vs Atletico Madrid | 1 - 0 | N/A |
| 2021-09-25 15:15:00September 25, 2021 | Valencia vs Athletic Club | 1 - 1 | N/A |
| 2021-09-25 17:30:00September 25, 2021 | Sevilla vs Espanyol | 2 - 0 | N/A |
| 2021-09-25 20:00:00September 25, 2021 | Real Madrid vs Villarreal | 0 - 0 | N/A |
| 2021-09-26 13:00:00September 26, 2021 | Mallorca vs Osasuna | 2 - 3 | N/A |
| 2021-09-26 15:15:00September 26, 2021 | Barcelona vs Levante | 3 - 0 | N/A |
| 2021-09-26 17:30:00September 26, 2021 | Real Sociedad vs Elche | 1 - 0 | N/A |
| 2021-09-26 17:30:00September 26, 2021 | Vallecano vs Cadiz | 3 - 1 | N/A |
| 2021-09-26 20:00:00September 26, 2021 | Real Betis vs Getafe | 2 - 0 | N/A |
| 2021-09-27 20:00:00September 27, 2021 | Celta vs Granada | 1 - 0 | N/A |
| 2021-10-01 20:00:00October 1, 2021 | Athletic Club vs Alaves | 1 - 0 | N/A |
| 2021-10-02 13:00:00October 2, 2021 | Osasuna vs Vallecano | 1 - 0 | N/A |
| 2021-10-02 15:15:00October 2, 2021 | Mallorca vs Levante | 1 - 0 | N/A |
| 2021-10-02 17:30:00October 2, 2021 | Cadiz vs Valencia | 0 - 0 | N/A |
| 2021-10-02 20:00:00October 2, 2021 | Atletico Madrid vs Barcelona | 2 - 0 | N/A |
| 2021-10-03 13:00:00October 3, 2021 | Elche vs Celta | 1 - 0 | N/A |
| 2021-10-03 15:15:00October 3, 2021 | Espanyol vs Real Madrid | 2 - 1 | N/A |
| 2021-10-03 17:30:00October 3, 2021 | Getafe vs Real Sociedad | 1 - 1 | N/A |
| 2021-10-03 17:30:00October 3, 2021 | Villarreal vs Real Betis | 2 - 0 | N/A |
| 2021-10-03 20:00:00October 3, 2021 | Granada vs Sevilla | 1 - 0 | N/A |
| 2021-10-16 17:30:00October 16, 2021 | Levante vs Getafe | 0 - 0 | N/A |
| 2021-10-16 20:00:00October 16, 2021 | Real Sociedad vs Mallorca | 1 - 0 | N/A |
| 2021-10-17 13:00:00October 17, 2021 | Vallecano vs Elche | 2 - 1 | N/A |
| 2021-10-17 15:15:00October 17, 2021 | Celta vs Sevilla | 0 - 1 | N/A |
| 2021-10-17 17:30:00October 17, 2021 | Villarreal vs Osasuna | 1 - 2 | N/A |
| 2021-10-17 20:00:00October 17, 2021 | Barcelona vs Valencia | 3 - 1 | N/A |
| 2021-10-18 18:00:00October 18, 2021 | Alaves vs Real Betis | 0 - 1 | N/A |
| 2021-10-18 20:00:00October 18, 2021 | Espanyol vs Cadiz | 2 - 0 | N/A |
| 2021-10-22 20:00:00October 22, 2021 | Osasuna vs Granada | 1 - 1 | N/A |
| 2021-10-23 13:00:00October 23, 2021 | Valencia vs Mallorca | 2 - 2 | N/A |
| 2021-10-23 15:15:00October 23, 2021 | Cadiz vs Alaves | 0 - 2 | N/A |
| 2021-10-23 17:30:00October 23, 2021 | Elche vs Espanyol | 2 - 2 | N/A |
| 2021-10-23 20:00:00October 23, 2021 | Athletic Club vs Villarreal | 2 - 1 | N/A |
| 2021-10-24 13:00:00October 24, 2021 | Sevilla vs Levante | 5 - 3 | N/A |
| 2021-10-24 15:15:00October 24, 2021 | Barcelona vs Real Madrid | 1 - 2 | N/A |
| 2021-10-24 17:30:00October 24, 2021 | Real Betis vs Vallecano | 3 - 2 | N/A |
| 2021-10-24 20:00:00October 24, 2021 | Atletico Madrid vs Real Sociedad | 2 - 2 | N/A |
| 2021-10-25 20:00:00October 25, 2021 | Getafe vs Celta | 0 - 3 | N/A |
| 2021-10-26 18:00:00October 26, 2021 | Alaves vs Elche | 1 - 0 | N/A |
| 2021-10-26 20:00:00October 26, 2021 | Espanyol vs Athletic Club | 1 - 1 | N/A |
| 2021-10-26 20:30:00October 26, 2021 | Villarreal vs Cadiz | 3 - 3 | N/A |
| 2021-10-27 18:00:00October 27, 2021 | Mallorca vs Sevilla | 1 - 1 | N/A |
| 2021-10-27 18:00:00October 27, 2021 | Vallecano vs Barcelona | 1 - 0 | N/A |
| 2021-10-27 19:00:00October 27, 2021 | Real Betis vs Valencia | 4 - 1 | N/A |
| 2021-10-27 20:30:00October 27, 2021 | Real Madrid vs Osasuna | 0 - 0 | N/A |
| 2021-10-28 18:00:00October 28, 2021 | Celta vs Real Sociedad | 0 - 2 | N/A |
| 2021-10-28 19:00:00October 28, 2021 | Granada vs Getafe | 1 - 1 | N/A |
| 2021-10-28 20:30:00October 28, 2021 | Levante vs Atletico Madrid | 2 - 2 | N/A |
| 2021-10-30 13:00:00October 30, 2021 | Elche vs Real Madrid | 1 - 2 | N/A |
| 2021-10-30 15:15:00October 30, 2021 | Sevilla vs Osasuna | 2 - 0 | N/A |
| 2021-10-30 17:30:00October 30, 2021 | Valencia vs Villarreal | 2 - 0 | N/A |
| 2021-10-30 20:00:00October 30, 2021 | Barcelona vs Alaves | 1 - 1 | N/A |
| 2021-10-31 14:00:00October 31, 2021 | Cadiz vs Mallorca | 1 - 1 | N/A |
| 2021-10-31 16:15:00October 31, 2021 | Atletico Madrid vs Real Betis | 3 - 0 | N/A |
| 2021-10-31 18:30:00October 31, 2021 | Getafe vs Espanyol | 2 - 1 | N/A |
| 2021-10-31 21:00:00October 31, 2021 | Real Sociedad vs Athletic Club | 1 - 1 | N/A |
| 2021-11-01 18:30:00November 1, 2021 | Vallecano vs Celta | 0 - 0 | N/A |
| 2021-11-01 21:00:00November 1, 2021 | Levante vs Granada | 0 - 3 | N/A |
| 2021-11-05 21:00:00November 5, 2021 | Athletic Club vs Cadiz | 0 - 1 | N/A |
| 2021-11-06 14:00:00November 6, 2021 | Espanyol vs Granada | 2 - 0 | N/A |
| 2021-11-06 16:15:00November 6, 2021 | Celta vs Barcelona | 3 - 3 | N/A |
| 2021-11-06 18:30:00November 6, 2021 | Alaves vs Levante | 2 - 1 | N/A |
| 2021-11-06 21:00:00November 6, 2021 | Real Madrid vs Vallecano | 2 - 1 | N/A |
| 2021-11-07 14:00:00November 7, 2021 | Villarreal vs Getafe | 1 - 0 | N/A |
| 2021-11-07 16:15:00November 7, 2021 | Valencia vs Atletico Madrid | 3 - 3 | N/A |
| 2021-11-07 18:30:00November 7, 2021 | Mallorca vs Elche | 2 - 2 | N/A |
| 2021-11-07 18:30:00November 7, 2021 | Osasuna vs Real Sociedad | 0 - 2 | N/A |
| 2021-11-07 21:00:00November 7, 2021 | Real Betis vs Sevilla | 0 - 2 | N/A |
| 2021-11-19 21:00:00November 19, 2021 | Levante vs Athletic Club | 0 - 0 | N/A |
| 2021-11-20 14:00:00November 20, 2021 | Celta vs Villarreal | 1 - 1 | N/A |
| 2021-11-20 16:15:00November 20, 2021 | Sevilla vs Alaves | 2 - 2 | N/A |
| 2021-11-20 18:30:00November 20, 2021 | Atletico Madrid vs Osasuna | 1 - 0 | N/A |
| 2021-11-20 21:00:00November 20, 2021 | Barcelona vs Espanyol | 1 - 0 | N/A |
| 2021-11-21 14:00:00November 21, 2021 | Getafe vs Cadiz | 4 - 0 | N/A |
| 2021-11-21 16:15:00November 21, 2021 | Granada vs Real Madrid | 1 - 4 | N/A |
| 2021-11-21 18:30:00November 21, 2021 | Elche vs Real Betis | 0 - 3 | N/A |
| 2021-11-21 21:00:00November 21, 2021 | Real Sociedad vs Valencia | 0 - 0 | N/A |
| 2021-11-22 21:00:00November 22, 2021 | Vallecano vs Mallorca | 3 - 1 | N/A |
| 2021-11-26 21:00:00November 26, 2021 | Athletic Club vs Granada | 2 - 2 | N/A |
| 2021-11-27 14:00:00November 27, 2021 | Alaves vs Celta | 1 - 2 | N/A |
| 2021-11-27 16:15:00November 27, 2021 | Valencia vs Vallecano | 1 - 1 | N/A |
| 2021-11-27 18:30:00November 27, 2021 | Mallorca vs Getafe | 0 - 0 | N/A |
| 2021-11-27 21:00:00November 27, 2021 | Villarreal vs Barcelona | 1 - 3 | N/A |
| 2021-11-28 14:00:00November 28, 2021 | Real Betis vs Levante | 3 - 1 | N/A |
| 2021-11-28 16:15:00November 28, 2021 | Espanyol vs Real Sociedad | 1 - 0 | N/A |
| 2021-11-28 18:30:00November 28, 2021 | Cadiz vs Atletico Madrid | 1 - 4 | N/A |
| 2021-11-28 21:00:00November 28, 2021 | Real Madrid vs Sevilla | 2 - 1 | N/A |
| 2021-11-29 21:00:00November 29, 2021 | Osasuna vs Elche | 1 - 1 | N/A |
| 2021-12-01 21:00:00December 1, 2021 | Real Madrid vs Athletic Club | 1 - 0 | N/A |
| 2021-12-03 21:00:00December 3, 2021 | Granada vs Alaves | 2 - 1 | N/A |
| 2021-12-04 14:00:00December 4, 2021 | Sevilla vs Villarreal | 1 - 0 | N/A |
| 2021-12-04 16:15:00December 4, 2021 | Barcelona vs Real Betis | 0 - 1 | N/A |
| 2021-12-04 18:30:00December 4, 2021 | Atletico Madrid vs Mallorca | 1 - 2 | N/A |
| 2021-12-04 21:00:00December 4, 2021 | Real Sociedad vs Real Madrid | 0 - 2 | N/A |
| 2021-12-05 14:00:00December 5, 2021 | Vallecano vs Espanyol | 1 - 0 | N/A |
| 2021-12-05 16:15:00December 5, 2021 | Elche vs Cadiz | 3 - 1 | N/A |
| 2021-12-05 18:30:00December 5, 2021 | Levante vs Osasuna | 0 - 0 | N/A |
| 2021-12-05 21:00:00December 5, 2021 | Celta vs Valencia | 1 - 2 | N/A |
| 2021-12-06 21:00:00December 6, 2021 | Getafe vs Athletic Club | 0 - 0 | N/A |
| 2021-12-10 21:00:00December 10, 2021 | Mallorca vs Celta | 0 - 0 | N/A |
| 2021-12-11 14:00:00December 11, 2021 | Espanyol vs Levante | 4 - 3 | N/A |
| 2021-12-11 16:15:00December 11, 2021 | Alaves vs Getafe | 1 - 1 | N/A |
| 2021-12-11 18:30:00December 11, 2021 | Valencia vs Elche | 2 - 1 | N/A |
| 2021-12-11 21:00:00December 11, 2021 | Athletic Club vs Sevilla | 0 - 1 | N/A |
| 2021-12-12 14:00:00December 12, 2021 | Villarreal vs Vallecano | 2 - 0 | N/A |
| 2021-12-12 16:15:00December 12, 2021 | Osasuna vs Barcelona | 2 - 2 | N/A |
| 2021-12-12 18:30:00December 12, 2021 | Real Betis vs Real Sociedad | 4 - 0 | N/A |
| 2021-12-12 21:00:00December 12, 2021 | Real Madrid vs Atletico Madrid | 2 - 0 | N/A |
| 2021-12-13 21:00:00December 13, 2021 | Cadiz vs Granada | 1 - 1 | N/A |
| 2021-12-17 21:00:00December 17, 2021 | Celta vs Espanyol | 3 - 1 | N/A |
| 2021-12-18 14:00:00December 18, 2021 | Vallecano vs Alaves | 2 - 0 | N/A |
| 2021-12-18 16:15:00December 18, 2021 | Real Sociedad vs Villarreal | 1 - 3 | N/A |
| 2021-12-18 18:30:00December 18, 2021 | Barcelona vs Elche | 3 - 2 | N/A |
| 2021-12-18 21:00:00December 18, 2021 | Sevilla vs Atletico Madrid | 2 - 1 | N/A |
| 2021-12-19 14:00:00December 19, 2021 | Granada vs Mallorca | 4 - 1 | N/A |
| 2021-12-19 16:15:00December 19, 2021 | Athletic Club vs Real Betis | 3 - 2 | N/A |
| 2021-12-19 18:30:00December 19, 2021 | Getafe vs Osasuna | 1 - 0 | N/A |
| 2021-12-19 21:00:00December 19, 2021 | Real Madrid vs Cadiz | 0 - 0 | N/A |
| 2021-12-20 21:00:00December 20, 2021 | Levante vs Valencia | 3 - 4 | N/A |
| 2021-12-21 19:00:00December 21, 2021 | Villarreal vs Alaves | 5 - 2 | N/A |
| 2021-12-21 21:30:00December 21, 2021 | Sevilla vs Barcelona | 1 - 1 | N/A |
| 2021-12-22 19:00:00December 22, 2021 | Granada vs Atletico Madrid | 2 - 1 | N/A |
| 2021-12-22 21:30:00December 22, 2021 | Athletic Club vs Real Madrid | 1 - 2 | N/A |
| 2021-12-31 16:15:00December 31, 2021 | Valencia vs Espanyol | 1 - 2 | N/A |
| 2022-01-02 14:00:00January 2, 2022 | Getafe vs Real Madrid | 1 - 0 | N/A |
| 2022-01-02 16:15:00January 2, 2022 | Atletico Madrid vs Vallecano | 2 - 0 | N/A |
| 2022-01-02 16:15:00January 2, 2022 | Elche vs Granada | 0 - 0 | N/A |
| 2022-01-02 18:30:00January 2, 2022 | Alaves vs Real Sociedad | 1 - 1 | N/A |
| 2022-01-02 18:30:00January 2, 2022 | Real Betis vs Celta | 0 - 2 | N/A |
| 2022-01-02 21:00:00January 2, 2022 | Mallorca vs Barcelona | 0 - 1 | N/A |
| 2022-01-03 19:00:00January 3, 2022 | Villarreal vs Levante | 5 - 0 | N/A |
| 2022-01-03 21:00:00January 3, 2022 | Osasuna vs Athletic Club | 1 - 3 | N/A |
| 2022-01-03 21:15:00January 3, 2022 | Cadiz vs Sevilla | 0 - 1 | N/A |
| 2022-01-08 14:00:00January 8, 2022 | Levante vs Mallorca | 2 - 0 | N/A |
| 2022-01-08 16:15:00January 8, 2022 | Real Sociedad vs Celta | 1 - 0 | N/A |
| 2022-01-08 18:30:00January 8, 2022 | Granada vs Barcelona | 1 - 1 | N/A |
| 2022-01-08 21:00:00January 8, 2022 | Real Madrid vs Valencia | 4 - 1 | N/A |
| 2022-01-09 14:00:00January 9, 2022 | Vallecano vs Real Betis | 1 - 1 | N/A |
| 2022-01-09 16:15:00January 9, 2022 | Sevilla vs Getafe | 1 - 0 | N/A |
| 2022-01-09 18:30:00January 9, 2022 | Alaves vs Athletic Club | 0 - 0 | N/A |
| 2022-01-09 18:30:00January 9, 2022 | Osasuna vs Cadiz | 2 - 0 | N/A |
| 2022-01-09 21:00:00January 9, 2022 | Villarreal vs Atletico Madrid | 2 - 2 | N/A |
| 2022-01-10 21:00:00January 10, 2022 | Espanyol vs Elche | 1 - 2 | N/A |
| 2022-01-16 14:00:00January 16, 2022 | Elche vs Villarreal | 1 - 0 | N/A |
| 2022-01-18 20:00:00January 18, 2022 | Real Betis vs Alaves | 4 - 0 | N/A |
| 2022-01-18 21:30:00January 18, 2022 | Cadiz vs Espanyol | 2 - 2 | N/A |
| 2022-01-19 19:00:00January 19, 2022 | Celta vs Osasuna | 2 - 0 | N/A |
| 2022-01-19 20:00:00January 19, 2022 | Atletico Madrid vs Levante | 20:00:008:00 pm | N/A |
| 2022-01-19 20:00:00January 19, 2022 | Barcelona vs Vallecano | 20:00:00Postponed | N/A |
| 2022-01-19 20:00:00January 19, 2022 | Mallorca vs Real Sociedad | 20:00:00Postponed | N/A |
| 2022-01-19 21:30:00January 19, 2022 | Valencia vs Sevilla | 1 - 1 | N/A |
| 2022-01-20 19:00:00January 20, 2022 | Getafe vs Granada | 4 - 2 | N/A |
| 2022-01-21 21:00:00January 21, 2022 | Espanyol vs Real Betis | 1 - 4 | N/A |
| 2022-01-22 14:00:00January 22, 2022 | Levante vs Cadiz | 0 - 2 | N/A |
| 2022-01-22 16:15:00January 22, 2022 | Villarreal vs Mallorca | 3 - 0 | N/A |
| 2022-01-22 18:30:00January 22, 2022 | Sevilla vs Celta | 2 - 2 | N/A |
| 2022-01-22 21:00:00January 22, 2022 | Atletico Madrid vs Valencia | 3 - 2 | N/A |
| 2022-01-23 14:00:00January 23, 2022 | Granada vs Osasuna | 0 - 2 | N/A |
| 2022-01-23 16:15:00January 23, 2022 | Real Madrid vs Elche | 2 - 2 | N/A |
| 2022-01-23 18:30:00January 23, 2022 | Real Sociedad vs Getafe | 0 - 0 | N/A |
| 2022-01-23 18:30:00January 23, 2022 | Vallecano vs Athletic Club | 0 - 1 | N/A |
| 2022-01-23 21:00:00January 23, 2022 | Alaves vs Barcelona | 0 - 1 | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Athletic Club vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Barcelona vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Real Betis vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Celta vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Mallorca vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Getafe vs Levante | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Osasuna vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Real Madrid vs Granada | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Valencia vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-02-06 20:00:00February 6, 2022 | Elche vs Alaves | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Alaves vs Valencia | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Atletico Madrid vs Getafe | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Mallorca vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Cadiz vs Celta | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Espanyol vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Levante vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Real Sociedad vs Granada | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Sevilla vs Elche | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Vallecano vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-02-13 20:00:00February 13, 2022 | Villarreal vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Athletic Club vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Real Betis vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Celta vs Levante | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Cadiz vs Getafe | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Granada vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Espanyol vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Osasuna vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Real Madrid vs Alaves | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Valencia vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-02-20 20:00:00February 20, 2022 | Elche vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Atletico Madrid vs Celta | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Barcelona vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Mallorca vs Valencia | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Getafe vs Alaves | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Granada vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Levante vs Elche | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Real Sociedad vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Sevilla vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Vallecano vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-02-27 20:00:00February 27, 2022 | Villarreal vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Alaves vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Athletic Club vs Levante | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Real Betis vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Celta vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Cadiz vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Espanyol vs Getafe | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Osasuna vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Real Madrid vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Valencia vs Granada | 20:00:008:00 pm | N/A |
| 2022-03-06 20:00:00March 6, 2022 | Elche vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Atletico Madrid vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Barcelona vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Real Betis vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Mallorca vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Getafe vs Valencia | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Granada vs Elche | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Levante vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Real Sociedad vs Alaves | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Vallecano vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-03-13 20:00:00March 13, 2022 | Villarreal vs Celta | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Alaves vs Granada | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Athletic Club vs Getafe | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Celta vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Cadiz vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Espanyol vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Osasuna vs Levante | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Real Madrid vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Sevilla vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Vallecano vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-03-20 20:00:00March 20, 2022 | Elche vs Valencia | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Athletic Club vs Elche | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Atletico Madrid vs Alaves | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Barcelona vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Real Betis vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Celta vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Getafe vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Granada vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Levante vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Real Sociedad vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-04-03 20:00:00April 3, 2022 | Valencia vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Mallorca vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Cadiz vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Espanyol vs Celta | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Levante vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Osasuna vs Alaves | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Real Madrid vs Getafe | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Sevilla vs Granada | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Vallecano vs Valencia | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Villarreal vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-04-10 20:00:00April 10, 2022 | Elche vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Alaves vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Athletic Club vs Celta | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Atletico Madrid vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Barcelona vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Getafe vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Granada vs Levante | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Real Sociedad vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Sevilla vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Valencia vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-04-17 20:00:00April 17, 2022 | Elche vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Atletico Madrid vs Granada | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Real Betis vs Elche | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Celta vs Getafe | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Mallorca vs Alaves | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Cadiz vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Espanyol vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Levante vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Osasuna vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Real Sociedad vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-04-20 20:00:00April 20, 2022 | Villarreal vs Valencia | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Alaves vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Athletic Club vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Barcelona vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Getafe vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Granada vs Celta | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Real Madrid vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Sevilla vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Valencia vs Levante | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Vallecano vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-05-01 20:00:00May 1, 2022 | Elche vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Athletic Club vs Valencia | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Atletico Madrid vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Real Betis vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Celta vs Alaves | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Mallorca vs Granada | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Getafe vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Cadiz vs Elche | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Espanyol vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Levante vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-05-08 20:00:00May 8, 2022 | Villarreal vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Alaves vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Barcelona vs Celta | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Granada vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Osasuna vs Getafe | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Real Madrid vs Levante | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Real Sociedad vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Sevilla vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Valencia vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Vallecano vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-05-11 20:00:00May 11, 2022 | Elche vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Athletic Club vs Osasuna | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Atletico Madrid vs Sevilla | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Real Betis vs Granada | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Celta vs Elche | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Mallorca vs Vallecano | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Getafe vs Barcelona | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Cadiz vs Real Madrid | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Espanyol vs Valencia | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Levante vs Alaves | 20:00:008:00 pm | N/A |
| 2022-05-15 20:00:00May 15, 2022 | Villarreal vs Real Sociedad | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Alaves vs Cadiz | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Barcelona vs Villarreal | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Granada vs Espanyol | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Osasuna vs Mallorca | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Real Madrid vs Real Betis | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Real Sociedad vs Atletico Madrid | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Sevilla vs Athletic Club | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Valencia vs Celta | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Vallecano vs Levante | 20:00:008:00 pm | N/A |
| 2022-05-22 20:00:00May 22, 2022 | Elche vs Getafe | 20:00:008:00 pm | N/A |
